<div dir="ltr">That is information that is definitely useful to me! Thanks so much! Do you know what dosage of Winstrol I should ask for for a 6.8 pound cat? I want to have as much info as possible when I talk to my vet on Monday.<br></div><div class="gmail_extra"><br><div class="gmail_quote">On Fri, Dec 16, 2016 at 4:25 PM, Amani Oakley <span dir="ltr"><<a href="mailto:aoakley@oakleylegal.com" target="_blank">aoakley@oakleylegal.com</a>></span> wrote:<br><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">No Randy, Winstrol is an anabolic steroid (unlike prednisone which is a corticosteroid) so it does not have a dampening effect on the immune system. What you
need right now is something to stimulate red cell production. If your cat has FELV, then the problem is that the progenitor cells in the bone marrow will have been infiltrated/killed by the virus and thus, the red cell production is down. Red cells have a
life span of 120 days in circulation, so once that is over and they die, then they must be replenished by a steady supply of new cells from the bone marrow.
<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">The only thing I have found that will do that is Winstrol. However, I use it in a cocktail with Doxycycline which has been found to retard the reproduction of
viral RNA, and prednisone. This is the only combination of drugs that worked when my cat was in FELV crisis and had a haematocrit result of 5 (with the reference range being something like 25 to 35, off the top of my head). I had tried LTCI and interferon
and even though I tested his blood weekly, I saw no change/improvement at all in his red cell count, haematocrit, hemoglobin, platelets, etc. It was only when I stumbled upon the use of Winstrol (he was already on prednisone and Doxy, but they don’t work without
the Winstrol), that I saw a steady and sustained improvement in his haematology numbers.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">The scandal, Randy, is that Winstrol is one of the steroids often implicated in athletic doping scandals, so vets seem to be gun shy about prescribing it. Also,
some years ago, a very poorly conducted experiment was published where cats where given 10 times the recommended dose of Winstrol as a “loading dose” and developed liver problems. So between these two driving forces, you have a lot of uneducated vets who will
either think you are “unethical” for asking for the Winstrol, or believe it is a harmful drug thanks to the stupid scientific study that was published. Plus, even where they are willing to prescribe it (like in Sherri’s case) they don’t recognize the need
to couple it with the Doxycycline, and thus, you do get a weak boost of the red cells, etc., but the virus is reproducing rampantly, so in the end, the virus wins. (Then, of course, not recognizing the need for the Doxy, those same vets will view the use of
Winstrol as a failure and not likely use it again.)<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">Other medications that might increase red cell production are erythropoietin and related medications, but erythropoietin does not encourage bone marrow growth
and development as Winstrol does. Thus, if the progenitor cells in the bone marrow, which produce red cells, white cells and platelets, have been killed by the virus (or converted to infected cells, spewing out more virus) then the erythropoietin will not
be effective because it simply encourages those progenitor cells to produce more red cells. However, because they can’t and thus cannot respond to the stimulation by erythropoietin. (If your cat doesn’t have FELV, and has anemia because of some other cause,
then the erythropoietin might work.)<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">Winstrol stimulates bone production (experiments have used it effectively in older adults for osteoporosis), and I don’t anything else which fits the bill.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">Cats with FELV often also have lymphocytes lining the intestinal walls, or other problems with moving food through the intestines. My cat did, and that resulted
in (a) loss of appetite (b) vomiting and (c) slow bowel movements. I therefore found it necessary to add a ¼ tablet of metoclompromine (Reglen) before meal times twice a day. Worked like a charm.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">This cocktail then brought my baby back from the brink of certain death. I had given him blood transfusions with his anemia, but that is only a short-term solution
and he wasn’t producing any red cells (reticulocyte count was basically zero – this is a measure of new red cell production and should be increased in cases of anemia to demonstrate that the body is producing red cells to compensate for the reduced red cell
count). He had had a reaction with his last blood transfusion, and so no more transfusions were possible since the next one would kill him, and I was all out of options as I watched his haematocrit level drop lower and lower, week by week. It had dropped to
10 when I “discovered” an old bottle of Winstrol in my drawer.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">Whew. Guess how many times I have given this speech??<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d">Amani<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"" lang="EN-US">From:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"" lang="EN-US"> Felvtalk [<a href="mailto:felvtalk-bounces@felineleukemia.org" target="_blank">mailto:felvtalk-bounces@<wbr>felineleukemia.org</a>]
<b>On Behalf Of </b>Randy Henke<br>
<b>Sent:</b> December-16-16 9:15 AM<span class=""><br>
<b>To:</b> <a href="mailto:felvtalk@felineleukemia.org" target="_blank">felvtalk@felineleukemia.org</a><br>
<b>Subject:</b> Re: [Felvtalk] Questioning FELV diagnosis<u></u><u></u></span></span></p>
<p class="MsoNormal"><u></u> <u></u></p>
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<p class="MsoNormal">It's interesting that our vet was very hesitant about even prescribing Prednisone because he is afraid it will suppress her immunity to secondary infections. I know that is a risk. Would adding Winstrol suppress her immune system even further?
I'm very confused about how to proceed.<u></u><u></u></p>
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<p class="MsoNormal">On Thu, Dec 15, 2016 at 10:23 PM, Ardy Robertson <<a href="mailto:ardyr@centurytel.net" target="_blank">ardyr@centurytel.net</a>> wrote:<u></u><u></u></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"" lang="EN-US">If I can chime in on Winstrol, it did wonders on my Tigger to get his bloodwork up. I only wish I
had started it sooner, along with the prednisolone and doxycycline.</span><span lang="EN-US"><u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-family:"Calibri","sans-serif"" lang="EN-US">Best of luck!</span><span lang="EN-US"><u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-family:"Calibri","sans-serif"" lang="EN-US">Ardy</span><span lang="EN-US"><u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"" lang="EN-US"> </span><span lang="EN-US"><u></u><u></u></span></p>
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