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<DIV><FONT size=2 face=Arial>Hi Amani.</FONT></DIV>
<DIV><FONT size=2 face=Arial></FONT> </DIV>
<DIV><FONT size=2 face=Arial>Thanks for the article. Sounds
promising. </FONT></DIV>
<DIV><FONT size=2 face=Arial></FONT> </DIV>
<DIV><FONT size=2 face=Arial>Jane</FONT></DIV>
<BLOCKQUOTE
style="BORDER-LEFT: #000000 2px solid; PADDING-LEFT: 5px; PADDING-RIGHT: 0px; MARGIN-LEFT: 5px; MARGIN-RIGHT: 0px">
<DIV style="FONT: 10pt arial">----- Original Message ----- </DIV>
<DIV
style="FONT: 10pt arial; BACKGROUND: #e4e4e4; font-color: black"><B>From:</B>
<A title=aoakley@oakleylegal.com href="mailto:aoakley@oakleylegal.com">Amani
Oakley</A> </DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A title=felvtalk@felineleukemia.org
href="mailto:felvtalk@felineleukemia.org">felvtalk@felineleukemia.org</A>
</DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Tuesday, May 17, 2016 3:07 PM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> Re: [Felvtalk] doxy</DIV>
<DIV><BR></DIV>
<DIV class=WordSection1>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt">Hi
Jane<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></P>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt">As
I mentioned in my previous posts, I am aware that no antibiotic KILLS viruses.
However, Doxycycline also interferes with RNA reproduction in ALL cells. In
mammalian cells, we have two sites for RNA synthesis, and so when the
Doxycycline blocks one of the sites, mammalian cells can still proceed with
RNA synthesis. That isn’t the case with bacterial, and other organisms like
protozoa and mycoplasma. Doxycycline has been also found to block RNA
synthesis in some viruses. For example, search online for the following
article and you will see that scientific trials have shown that the
Doxycycline (which is a tetracycline derivative) blocked the ability of the
virus to enter cells and replicate. <o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></P>
<P class=MsoNormal><I><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt">Inhibitory
effect of doxycycline against dengue virus replication in vitro – Arch Virol.
May 29, 2013 – “Doxycycline is an antibiotic derived from tetracycline that
possesses antimicrobial and anti-inflammatory activities. <B>Antiviral
activity of doxycycline against dengue virus has been previously
reported.</B>”<B><o:p></o:p></B></SPAN></I></P>
<P class=MsoNormal><B><I><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></I></B></P>
<P class=MsoNormal><B><I><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt">“.
. . It is efficiently used to treat some tick-borne infections and is also
recommended as a first line therapy for sexually transmitted diseases as
herpes simplex infections [caused by a virus]. Combining doxycycline with
monocaprin provides an effective treatment for herpes labialis [another
virus], significantly reducing time to healing and pain compared to moncaprin
alone. Furthermore, antiviral activity of doxycycline has been reported
against retroviruses, and a significant reduction in retrovirus titer was
observed after incubation of infected cells with doxycycline. Previous studies
have shown that doxycycline inhibits dengue virus plaque formation disrupting
the conformational changes in the viral envelope that are necessary for viral
entry . . . In this study, we determined the anti-dengue properties of
doxycycline against four dengue virus serotypes in vitro. The results showed
that doxycycline interfered with dengue virus protease and impaired virus
binding to the host cells, leading to reduced viral replication in infected
cells. Taken together, our results form a strong basis to warrant further
experimental and clinical investigations towards reducing dengue morbidity by
utilizing doxycycline and anti-inflammatory
activities.”<o:p></o:p></SPAN></I></B></P>
<P class=MsoNormal><B><I><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></I></B></P>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt">With
some careful digging, you will find references to the use of doxycycline (and
other tetracyclines) to inhibit viral replication. I don’t have more time
today to find more of these articles for you, but they are there for the
finding.<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></P>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt">Amani<o:p></o:p></SPAN></P>
<P class=MsoNormal><B><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: #1f497d; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></B></P>
<DIV>
<DIV
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<P class=MsoNormal><B><SPAN
style="FONT-FAMILY: 'Tahoma','sans-serif'; FONT-SIZE: 10pt"
lang=EN-US>From:</SPAN></B><SPAN
style="FONT-FAMILY: 'Tahoma','sans-serif'; FONT-SIZE: 10pt" lang=EN-US>
Felvtalk [mailto:felvtalk-bounces@felineleukemia.org] <B>On Behalf Of </B>Jane
Gannon<BR><B>Sent:</B> May-17-16 4:44 PM<BR><B>To:</B>
felvtalk@felineleukemia.org<BR><B>Subject:</B> [Felvtalk]
doxy<o:p></o:p></SPAN></P></DIV></DIV>
<P class=MsoNormal><o:p> </o:p></P>
<DIV>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; FONT-SIZE: 10pt">Doxycycline ia an
antibiotic for bacterial infections, not for viral infections. It
works by interferring with the normal growth cycle of the bacteria preventing
them from reproducing and allowing the body to fight off the
infection. It is used against mycoplasma including mycoplasma
haemofelis, whcih is a blood parasite that causes anemia and death in
cats I have had a couple of cats die from it and a couple that I
have saved. This disease is transmitted by fleas so it is
important to use flea products on our cats. Doxy should be given with
food or on a full stomach to reduce chance of vomiting. It is suggested
that you give a syringe of water after pilling because it is possible for the
tablets to become stuck in the esophagus which can cause irritaftion or
scarring and can make it difficult for your cat to swallow. I crush it
and mix it with water and syringe it. </SPAN><o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal> <o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; FONT-SIZE: 10pt">In the book
"Secrets of a vet tech-the guide to low cost pet care when the cupboard is
bare" by J C Farris, she tells that you can use fish meds on cats and purchase
them on line or in some pet stores without a script This includes doxy
(fish doxy), amoxicillan (fish mox), metronidazole (fish zole), clindamycin
(fish cin), cephalexen (fish flex), ciprofloxacin (fish flox) and
others. This is the same exact medication for dogs and cats.
She has alot of other great ideas in this book. Dosages for these
medications for cats can be found on line. </SPAN><o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal> <o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; FONT-SIZE: 10pt">I just had my 5 yr
old positive, Tootsie, stop eating and drinking. She had vomited for a
couple of days before. She had no fever and no symptoms of upper
respiratory so I didn't want to start antibiotics. I tried everytlhing to
get her to eat. Then I remembered pepcid ac was prescribed by a vet
years ago for another cat (not a positive) with the same symptoms, so I tried
it on Tootsie. Four days later she is looking for food and eating
everything I give her. This is also used for kidney cats that loose
their appetite. </SPAN><o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal> <o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; FONT-SIZE: 10pt">Now I am going to
try pepcid ac on my older positive cat, Finn, who is recovering from
a seizure and temporary blindness. She is not eating well and I remember
before she had her seizure she had vomited for a couple of days and
was already not eating well. I will let you know if it
works.</SPAN><o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal> <o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal><SPAN
style="FONT-FAMILY: 'Arial','sans-serif'; FONT-SIZE: 10pt">Jane</SPAN><o:p></o:p></P></DIV>
<P class=MsoNormal><o:p> </o:p></P>
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