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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">Here is the excerpt from The Merck Veterinary Manual, in the chapter entitled “Drugs Acting on the Blood or Blood-forming Organs”:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="mmpara"><b>Anabolic steroids</b> are compounds structurally related to testosterone that have similar protein-anabolic activity but minimal androgenic effects, such as masculinization. As part of their anabolic activity, these compounds increase the
circulating RBC mass and possibly granulocytic mass. Clinical indications for use of anabolic steroids include chronic, nonregenerative anemias. Response to therapy is variable, and the time to clinical improvement is long, frequently ≥3 mo. The proposed mechanisms
of action include increased ERP production via ERP-stimulating factor, differentiation of stem cells into ERP-stimulating factor-sensitive cells (eg, hemocytoblasts), and direct stimulation of erythroid-progenitor cells. The effect of anabolic steroids requires
adequate ERP levels and sufficient cells in the bone marrow. Thus, the effectiveness of anabolic steroids in treating anemia may be limited, depending on the cause.<o:p></o:p></p>
<p class="mmpara"><a name="v3329814"></a>Anabolic steroids can be divided into 2 categories depending on the presence or absence of an alkyl group at the 17-carbon position. They are available as oral and parenteral preparations, including oil-based products
intended for slow release. The absorption and disposition of anabolic steroids depend on the type of preparation and the animal species. Most are eliminated after hepatic metabolism. The alkylated products are more effectively absorbed when given PO and are
more effective stimulants of bone marrow. Alkylated anabolic steroids include oxymetholone (dogs and cats: 1–5 mg/kg, PO, every 18–24 hr). Nonalkylated anabolic steroids include nandrolone decanoate (dogs: 1–1.5 mg/kg, IM/wk; cats: 1 mg/kg, IM/wk; horse: 1
mg/kg, IM, once every 4 wk). Boldenone undecylenate is approved for horses at 1.1 mg/kg, IM, every 3 wk. Side effects of anabolic steroids include sodium and water retention, virilization, and hepatotoxicity. The alkylated products are more hepatotoxic than
the non-alkylated products, particularly in cats. Cholestatic liver damage develops early and can be significant but frequently is reversible.<o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> Felvtalk [mailto:felvtalk-bounces@felineleukemia.org]
<b>On Behalf Of </b>Maya D'Alessio<br>
<b>Sent:</b> October-20-15 1:21 PM<br>
<b>To:</b> felvtalk@felineleukemia.org<br>
<b>Subject:</b> Re: [Felvtalk] Merlot status update<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p>My vet is not supportive of winstrol treatment, does anyone know of any sources I could send him to change his mind?<o:p></o:p></p>
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<p class="MsoNormal">On Oct 20, 2015 11:34 AM, "Amani Oakley" <<a href="mailto:aoakley@oakleylegal.com">aoakley@oakleylegal.com</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">Hi Maya</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">The fever is secondary to everything else going on. Keep him on the rest of the stuff anyway, and just
add the Winstrol. My experience is that the fever will dissipate with the improvement of his blood counts, etc.</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">Amani</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> Felvtalk
[mailto:<a href="mailto:felvtalk-bounces@felineleukemia.org" target="_blank">felvtalk-bounces@felineleukemia.org</a>]
<b>On Behalf Of </b>Maya D'Alessio<br>
<b>Sent:</b> October-20-15 8:03 AM<br>
<b>To:</b> <a href="mailto:felvtalk@felineleukemia.org" target="_blank">felvtalk@felineleukemia.org</a><br>
<b>Subject:</b> Re: [Felvtalk] Merlot status update</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p>Does the winstrol work on the fever though?<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">On Oct 20, 2015 3:21 AM, "Amani Oakley" <<a href="mailto:aoakley@oakleylegal.com" target="_blank">aoakley@oakleylegal.com</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">Maya</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">No matter what the outcome is of the temperature, I would suggest you start him on the Winstrol anyway.
This is an omen of things to come. The virus is in there and causing a problem. It is unlikely to go away on its own. Don’t wait until he is doing badly to start the Winstrol.</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">Again, with Zander, we saw very much the same course. Some abnormal haematology results, some lack
of appetite, temperature, licking concrete. That was in June/July. We took him to the vets, he got some antibiotics and seemed to improve. Then in September, a HUGE crash back into serious illness and we almost didn’t get him back.</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">If Merlot’s platelets dropped like that, the virus is affecting his bone marrow. Don’t wait until the
effects are far-reaching and difficult to reverse. Athletes use Winstrol to build up their muscles and stamina and to repair damages tissue. My suggestion is that you use it as a supportive measure now and head off the very likely future crisis, even if it
appears that you have achieved a bit of a reprieve now.</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">Amani</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> Felvtalk
[mailto:<a href="mailto:felvtalk-bounces@felineleukemia.org" target="_blank">felvtalk-bounces@felineleukemia.org</a>]
<b>On Behalf Of </b>Maya D'Alessio<br>
<b>Sent:</b> October-19-15 11:19 PM<br>
<b>To:</b> <a href="mailto:felvtalk@felineleukemia.org" target="_blank">felvtalk@felineleukemia.org</a><br>
<b>Subject:</b> [Felvtalk] Merlot status update</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:9.5pt">So we can say relatively conclusively at this point that this is the FeLV, as his blood cell counts are going down and everything else has been ruled
out. </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:9.5pt">His fever hasn't changed, which is good and bad. Good that it's not worse, bad that it's not responding to drugs. We got to take him home tonight and
I've just got him settled in Phil's office, where I'll be sleeping with him for the night. He's definitely in better shape than this morning, more perky and like himself, but we are still on high alert.</span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:9.5pt">The vet says he has roughly a 40% chance of a good prognosis. She's seen cats come back from this with FeLV, and others don't. We are taking him in
first thing tomorrow to see the vet again and get re-evaluated, and we will make some more decisions about drugs at that point. The vet has agreed to try Winstrol tomorrow if the fever hasn't come down (he's on two antibiotics right now, an anti-nauseant and
she upped the prednisolone).</span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:9.5pt"><img border="0" id="_x0000_i1025" src="https://ssl.gstatic.com/ui/v1/icons/mail/images/cleardot.gif"></span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">--
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Maya D'Alessio<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">PhD student<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">B1 377B, x32320<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Graduate Studies Endowment Fund Coordinator<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Biology GSA Vice Chair<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">GSA Director At-Large<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">University of Waterloo<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.0pt"><br>
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