[Felvtalk] RNA effects of Doxy

Thu Mar 2 03:19:05 CST 2017

Thanks Amani... this is very helpful and I will do my best to locate 
these references... preferably the full articles if they don't charge 
too much for them ( I no longer work in hospitals and don't have access 
to full medical databases ( for free)...

VERY interesting about the ebola virus and the eyes.... it does indeed 
appear that the virus established a foothold in Yogi's eyes....   BUT... 
it was also via the eyes that I was able to introduce antiviral meds 
that my Veterinary opthalmologist was using off label.....  Of course 
the target for these meds was the Herpes Virus....but it too ,is,  a 
retro Virus and these meds "might" have had some effect on the FeLV 
virus as well
had I used them for a longer time ( though I would have had to have sold 
my house to do so : )
You can find ALL sorts of aid for these Anti Virals if you are using 
them for HIV or Herpes 1 or 2 but they are hard to locate at discount 
for Veterinary Use.....  I really am VERY concerned at the price of Vet 
services as I feel they will ultimately reduce the number of pet 
owners.....  I was able to easily afford to keep 4 cats on a rather low 
Social Worker income back in the 80's but keeping one ill FeLV in 2017 
can easily add 400.00 a month to ones expenses....  Many people who 
might formerly have adopted multiple cats will now only take in one or  
two.....  All the more reason for forums like ours as it is up to us to 
share our knowledge and experiences to help each other avoid total 
reliance on a veterinary system that is not always working to preserve 
our FeLV cats lives.....    

> Hi Bob
>
> I am unable to attach the literature regarding the ability of 
> Doxycycline to interfere with RNA replication and/or interfere with 
> viral infection, but here are a few titles to look up on the Internet:
>
> - Antiviral activity of doxycycline against vesicular stomatitis virus 
> in vitro - FEMS Microbiol Lett. 2015
>
> - Control of small inhibitory RNA levels and RNA interference by 
> doxycycline induced activation of a minimal RNA polymerase III 
> promoter - 2006 Nucleic Acids Res. 34
>
> - Inhibitory effect of doxycycline against dengue virus replication in 
> vitro - October 2013 Archives of Virology 159(4)
> - Study of the antiviral activity of some derivatives of tetracycline 
> and non-steroid anti-inflammatory drugs towards dengue virus - August 
> 2013 Tropical Biomedicine 30(4):1-10   (BY THE WAY - DOXYCYCLINE IS A 
> TETRACYCLINE)
>
> - A study of the clinical activity of a gel combining monocaprin and 
> doxycycline: a novel treatment for herpes labialis. (2012) J Oral Path 
> Med 41:61-67
>
>
>
> The following paper was interesting in that it explored the role of 
> Doxycycline in inhibiting tumour cell proliferation, angiogenesis, 
> metastasis and migration of cancerous cells (including leukemic cells) 
> from the bone marrow:
>
> - Doxycycline inhibits leukemic cell migration via inhibition of 
> matrix metalloproteinases and phosphorylation of focal adhesion kinase 
> - published Molecular Medicine Reports, September 2015 Vol. 12, Issue 
> 3.
>
>
> Amani
>
> P.S. - By the way, Bob. The other thing that was featured in that show 
> last night about the fight against Ebola, is that the same doctor who 
> contracted it and was declared symptom-free, later began to develop 
> eye problems and when they examined his eye, they found millions of 
> the Ebola viruses in the eye. The programme explained that the eye was 
> an area of reduced immunity in the body, and thus, the virus had found 
> a breeding ground where it remained, though it had been cleared from 
> the rest of the body. They therefore began treating the doctor's eye, 
> and the treatment was ultimately successful. It brought to mind the 
> problems Yogi had had with his eyes, and I wondered if the answer was 
> similar - that the virus had had a toe-hold there.
>
>
> -----Original Message-----
> From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf 
> Of ROBERT CHAPEL
> Sent: March-01-17 5:02 PM
> To: felvtalk at felineleukemia.org
> Cc: felvtalk at felineleukemia.org
> Subject: Re: [Felvtalk] Knowing the " whys" of Win/Pred/Doxy
>
> Amani...
>
> If we consider the extended time frame for Doxy and multiple courses 
> of other ABX it makes a certain "intuitive" sense that a non bacterial 
> infection is going to require a longer period of time to have whatever 
> non-specific ( read... not related to bacterial infection 
> necessarily)...? So little research money appears to be devoted to 
> FeLV that I don't know that we'll know in the next decade unless the 
> continuing demands of consumers ( who do NOT want to hear , in this 
> day and age of " Miracles") that there is _ no hope_ for their much 
> loved
> pets) alter this course.??? I STILL bristle when I think of the closed 
> minds in the medical and Veterinary community and SO resent that 
> businessmen( Yes...that is what the vast majority are turning into now 
> that practices are being forced to consolidate into " Health 
> Systems").. hold the power of life and death over us AND our pets.?? 
> On the plus side.... with the business model being what it is ( and in 
> contrast to the lost art of " professionalism")? The CONSUMER is 
> always right.? Vets will be forced, in the future, to work more 
> closely with the " customers" wishes as attachment to a given vet will 
> become less common as time goes on and people will " practice shop " 
> for the answers they want until such time as Vet services become so 
> expensive that insurance becomes a " must have " and ultimately go the 
> way of medicine ( ie...being confined to a slate of approved 
> practitioners... again....limiting choice)...? But... there are some 
> years to go before that happens and I feel that there IS a window of 
> opportunity happening NOW and for the next few? years for people to 
> have some real influence on how Vets practice....?? I am betting, for 
> example, that had I had the money to go to a more " well to do " 
> neighborhood where people are more demanding and better informed I 
> could have found a vet to cooperate... Here in the "sticks" people 
> just blindly accept what the vet has to say and they still enjoy the 
> freedom of calling all the shots.....?? This WILL end over the next 
> couple of years.? I learned a lot with this first experience and made 
> mistakes that I WILL NOT make again.
>
> BTW....? Do you have any literature in support of the AntiRNA effects 
> of Doxy...???? I am SO happy that there are still a couple of things 
> out there that we still can get our hands on that don't have to pass 
> muster with script pad businessmen....? STILL I am also not advocating 
> the the medically ill prepared take it upon themselves to decide that 
> THEY will decide what is best for their animal... If we are going to 
> go above and beyond our Vets advice it would best be with very sound 
> reasoning and an EXCELLENT understanding of what we are doing and 
> why.?? Anything less and the community of Veterinary practitioners 
> could easily dismiss our successes as "dumb luck" or ascribe them to " 
> unknown" factors.....? I think this is particularly important re: 
> Winstrol/Pred/Doxy?? I'd hate to see people going to their vets asking 
> for this combination of drugs and really having an inadequate 
> understanding of why they are asking for beyond the fact that it's 
> been recommended on our forum...??? For m
>  yself... I am clear on the Whys of Winstrol and Doxy ( though will be 
> looking for more lit support on the RNA effects of Doxy) but not clear 
> on the whys of the Pred.
> Sorry for taking up so much space here but I'm having an " attack " of 
> missing my little guy and am tremulous about being caught in the same 
> position if I take in another FeLV as I am inclined to do....
>
>>
>
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