[Felvtalk] Doxycycline

Mon Jun 26 21:14:16 CDT 2017

Amani - this is very interesting, at least the part that I understood :)

I agree that Big Pharma seems to just follow the money, it's not about helping our fellow man (or kitty) anymore, sadly.

And banning certain medicines because of their stigma, or potential use is just silly!!!
Ardy

-----Original Message-----
From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of Amani Oakley
Sent: Sunday, June 25, 2017 6:56 AM
To: felvtalk at felineleukemia.org
Subject: Re: [Felvtalk] Doxycycline

Ardy - there are a number of publications which deal with the mode of action of Doxycycline and its antiviral properties. It doesn’t kill the virus but inhibits its replication, sometimes by interfering with cell wall development and other times by preventing the virus from penetrating cells. Viruses usually replicate by invading a normal host cell, taking over its "machinery" and basically getting the host cell to make millions more viruses, which are then released into the circulation when the cell bursts. Doxycycline has been shown to sometimes inhibit the penetration of the virus into the cell.

So for example, Doxycycline has been found to be effective against Dengue fever. There are a number of publications exploring the effectiveness with Dengue fever. Here is an excerpt from a 2014 publication from the Archives of Virology (Inhibitory Effect of Doxycycline against Dengue Virus Replication in Vitro):

"Doxycycline is an antibiotic derived from tetracycline that possesses antimicrobial and anti-inflammatory activities. Antiviral activity of doxycycline against dengue virus has been reported previously; however, its anti-dengue properties need further investigation. This study was conducted to determine the potential activity of doxycycline against dengue virus replication in vitro. Doxycycline inhibited the dengue virus serine protease (DENV2 NS2B-NS3pro) with an IC50 value of 52.3 ± 6.2 μM at 37 °C (normal human temperature) and 26.7 ± 5.3 μM at 40 °C (high fever temperature). The antiviral activity of doxycycline was first tested at different concentrations against DENV2 using a plaque-formation assay. The virus titter decreased significantly after applying doxycycline at levels lower than its 50 % cytotoxic concentration (CC50, 100 μM), showing concentration-dependent inhibition with a 50 % effective concentration (EC50) of approximately 50 μM. Doxycycline significantly inhibited viral entry and post-infection replication of the four dengue serotypes, with serotype-specific inhibition (high activity against DENV2 and DENV4 compared to DENV1 and DENV3). Collectively, these findings underline the need for further experimental and clinical studies on doxycycline, utilizing its anti-dengue and anti-inflammatory activities to attenuate the clinical symptoms of dengue virus infection."

Doxycycline has also been found to be effective against West Nile virus, reovirus, Japanese encephalitis virus (JEV), vesicular stomatitis virus (in vitro), mural virus (a mouse virus which causes leukemia in mice), and more. Doxycycline is also effective against more unusual organisms like protozoa (eg - malaria) and the unusual bacteria which cause Lyme Disease and Rocky Mountain Spotted Fever.

Unbelievably, Doxycycline has also been shown to suppress metastatic cancer or assist in bone metastatses. I suspect this last finding is not a strong one since I don’t know that Doxycycline is routinely used for this. However, I sure wish I had known this when my family member was suffering from cancer. Again, under the category of "it might not do a darn thing but it's unlikely to be worse than the situation you're facing", I would have given this a try. There are quite a few publications looking at the use of Doxy for cancer though, so I think there is probably something there.

I doubt that anyone is studying the effect on the Feline Leukemia virus because I see little research involving cat conditions generally, and even less focused on the Feline Leukemia virus. I obviously went looking for an explanation as to why Doxycycline and Winstrol might have been effective with Zander, because I too had the general understanding that antibiotics are not effective against viruses (and I have a Microbiology degree!). I suspect that most physicians and vets have also had this "rule of thumb" hammered into their heads. It is generally true of course, but it obviously works to create a blind spot for physicians and vets, when it comes to the "exceptions" to this general rule. Also, what I have also come to understand is that when there is a drug like Doxycycline (and Winstrol), which has been around for a long time and the drug companies no longer have a patent on it, they can't make money on it, so they stop doing any research related to it. They focus their research on their new drugs on which they hold patents, so they can push these, and make more money.

And don’t even get me started on cannabis oil. To imagine where society might have been if we'd focused on researching the effects of cannabis on everything from cold sores to cancer for the last 100 years, is to truly despair at the sheer stupidity and duplicity of governments and certain people with devious designs. Oh, and cannabis' entirely benign cousin - hemp - which got swept into the ban for no legitimate reason at all - is able to be used for everything from a food source, to clothing, to fertilizer, to flooring, to automobile manufacturing, to building materials, to making non-toxic and biodegradable plastics AND A NONTOXIC ALTERNATIVE TO PETROCARBONS. (For a mind-blowing exercise, look up Henry Ford's first car made of hemp!) 

The more we learn, the more sad the picture gets. However, just maybe this Internet thing will allow us not to be so easily manipulated by our leaders (one hopes). 

Amani  

-----Original Message-----
From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of Ardy Robertson
Sent: June-24-17 9:36 AM
To: felvtalk at felineleukemia.org
Subject: Re: [Felvtalk] Lysine

Thanks Amani - I am also very intrigued by Doxycycline being able to, I believe you said - possibly stop the FeLV virus from replicating. Is this being studied and tested by vets, schools, etc.?

I also through it was said that the cannibas oil stopped the herpes virus of cold sores - my word - I thought we had nothing to defeat viruses. Docs always say "it's a virus, it has to run its course" - well maybe not! Yet they aren't looking at obvious sources just because of its third cousin - "weed". Good grief!

Rant over!
Ardy

-----Original Message-----
From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of Amani Oakley
Sent: Friday, June 23, 2017 11:16 PM
To: felvtalk at felineleukemia.org
Subject: Re: [Felvtalk] Lysine

Ardy, I think it was precisely because of my experience with Winstrol that I was open to the unthinkable thought that science and scientists weren’t always free to produce unbiased research, even when it could help a lot of animals or people.

I am, first and foremost, a scientist by training and inclination, and this concept was terribly foreign to me when I first stumbled upon the bizarre Winstrol situation. 

Amani

-----Original Message-----
From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of Ardy Robertson
Sent: June-24-17 12:12 AM
To: felvtalk at felineleukemia.org
Subject: Re: [Felvtalk] Lysine

Sort of like the stigma surrounding Winstrol due to the misuse of it by an Olympic athlete....... people and animals who could be helped by it are not. People are crazy sometimes.

Ardy

-----Original Message-----
From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of Amani Oakley
Sent: Wednesday, June 21, 2017 12:42 PM
To: felvtalk at felineleukemia.org
Subject: Re: [Felvtalk] Lysine

Cannabis is an absolutely amazing product. Do your own research. You will see very solid scientific evidence that backs up the many positive effects this substance has. In fact, I was pretty enraged when I did the research. It is clear that the decision to ban this substance was fraught with racial overtones, and was introduced simply because after the demise of prohibition, the government agency tasked with enforcing prohibition, needed a new mandate. It is also appalling that because of this ill-conceived war on drugs, and placing cannabis on Schedule 1 in the United States, virtually all scientific testing was either banned completely, or faced so many obstacles, that most scientists avoided doing any research on it at all. Thus, much of the scientific studies come from Spain and Israel. Oddly enough, when a pharmaceutical company decided to extract one of the key substances from the cannabis plant and market it as Marinol, it suddenly went from having no known medicinal qualities (the criteria to have it listed in Schedule 1) to being a very effective drug which can be marketed and can make lots of money for the drug company.

Do your own research. There is tons of stuff on the internet. There are Harvard professors and top-notch researchers turning out excellent, amazing research regarding the healing powers of this substance.

Oh, and the reason why so many of the States are now recognizing it for its medicinal qualities and legalizing it, is because it is unbelievably effective in helping young children suffering from severe forms of epilepsy where they literally convulse hundreds of times an hour, and the only medications heretofore even slightly effective would put these children into complete zombie states. Cannabis not only relieves the unbearable non-stop seizures, but doesn’t affect the children's level of consciousness. Parents in states which have not legalized marijuana have literally moved their whole families to other states to access medical marijuana when they have children suffering these syndromes. Even Republicans have in some instances been moved to back bills legalizing medical marijuana, when they have been confronted with these suffering children. Medical marijuana has also been found to be very effective for PTSD states, such as those suffered by servicemen and women who have served overseas and have witnessed traumatic events. 

With respect to cancer therapy, one of the worst cancers is the glioma which occurs in the brain. With such a diagnosis, most patients were dead within 6 months. Spanish researchers have recently shown that in mice with experimentally-induced gliomas, and treated with cannabinoids, 1/3 showed complete resolution of the glioma, 1/3 showed a standstill in the development of the glioma, and 1/3 showed no improvement. Given that nothing else has been found to be consistently helpful in treating gliomas, these results are nothing short of earth-shattering. 

Read and learn. I cry when I think of all the people who might have been helped if not for the conspiracy related to this drug. It is deeply deeply disturbing.

Amani

-----Original Message-----
From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of dlgegg at windstream.net
Sent: June-21-17 4:26 AM
To: felvtalk at felineleukemia.org
Cc: ROBERT CHAPEL
Subject: Re: [Felvtalk] Lysine

I agree on the cannibinol.  I wonder if maybe some of this is to justify making it legal saying it is for medical reasons.  It can't be all that wonderful, nothing is and when someone tells me that, I get suspicious.

---- ROBERT CHAPEL <bchapel at optonline.net> wrote: 
> 

Amy....
I'm not able to link to the article simply because it was not something I held on to...  At the time I had two FeLV+ young cats and I did NOT want to hear that one of the few things that I COULD do for them was useless....  I mentioned it to a couple of vets who were rather insistent that it IS useful....  Yes/No Maybe so  : )  I chose to believe and did not make a point of keeping the article for reference...  and Amani ( if you happen to read this)  I am getting hopeful about all of the uses of cannabinol ( though I AM suspect when something is said to be useful for everything from Cancer to Transmission Trouble in Oldsmobiles)...  With all the Hoopla there must be a pony in there somewhere..

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