[Felvtalk] FeLv Positive cat

[Sandy]

this is from previous posts - get your kitty cat to a vet - hopefully - who will not be afraid to "go outside" the box. 



Winstrol – 1 mg twice a day 



Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day 



Prednisolone – ½ 5 mg tablet, twice a day 





If there are problems with the intestines (vomiting, constipation, slow moving stools, stools of large diameters, all of which might be indicative of the effect of the virus on the intestines) you can try adding ¼ tablet of apometocloprimide. 



If the haematocrit level is REALLY REALLY low – like below 5-8, you might consider starting the Winstrol at 2 mg twice a day for a week, to try and kickstart things quickly, but given that there is going to be a likely increase in liver enzymes with the use of Winstrol, recognize that this might also increase the liver enzymes faster. 



Hope this helps! Amani 



From: Felvtalk [ mailto:felvtalk-bounces at felineleukemia.org ] On Behalf Of gary 
Sent: January-27-17 4:04 PM 
To: felvtalk at felineleukemia.org 
Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV 

Amani, 

Could you please give the dosages used for Zander's Protocol? I know they must have been previously given, but I cannot seem to find them. 

Thanks, Gary 

On 9/16/2016 8:52 AM, Amani Oakley wrote: 

Hi Sherri 



I hope you got some good news today. However, as you know, my experience is that the Winstrol needs to be used long term before the red cells are back into the normal range. I continue to recommend use of the Doxycyline to interfere with viral RNA synthesis. The Winstrol does not attack the virus, though I believe it makes the cat stronger overall and able to fight back. But at the outset of the treatment regime, I believe you must have the Doxycycline on board to try and reduce the viral load, or at least, keep it from rising. 



Amani 

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Hi Liz 



The only thing that works to turn back on red cell production is Winstrol (Stanazolol). It is an ANABOLIC steroid (as opposed to most steroids we are used to getting, like prednisone, which is a corticosteroid. 



Anabolic steroids are ones which build muscle, tissue, etc. 



Adding Winstrol to the combination of medication you have your cat on right now, would be the best thing to do. The Doxycycline acts to slow down or inhibit the reproduction of the FeLV virus by interfering the RNA duplication. The prednisone is helpful in keeping inflammation at bay, but neither of these helps to increase the red cells. The Winstrol acts directly and very quickly on the bone marrow and seems to get red cells generated again, quite promptly. At least it did for my Zander, and I have been contacted directly by several people from this group, who have reported to me that they also saw almost immediate (within 3 days) evidence of their cats’ gums/ears/pads pinkening up. 



The problem is that Winstrol is a controversial drug because it is also what professional athletes use to get bigger, stronger and faster. Quite unfortunately (since none of our cats are entering the Olympics) that association with doping scandals has cast a shadow on its use in both animal and people medicine. In human medicine, it is the only drug found to be effective in treating hereditary angioedema and anemia. 



Here is a blurb I found about it: 



Winstrol was first invented in 1959. Soon after that, the UK based Winthrop Laboratories created a prescription medicine from it. Later, in 1961, Winthrop’s patent was bought by the US based Sterling that started manufacturing and selling the drug in the American markets. 

In the beginning, Winstrol was used for a variety of medical reasons. But later, by the 1970s, the FDA had restricted its use to only promoting growth and treating osteoporosis. In the 1980s, there was a termination of the manufacture of anabolic steroids in the American market. But Winstrol was among those steroids which not only survived, but thrived in the 1980s and 1990s. During this period, its use was reinforced as a cure for anemia – as it had the power to boost red blood cell count, and was used as a treatment for facial swelling or angioedema. 

When the manufacture of Winstrol was finally discontinued, Ovation Pharmaceuticals bought the rights to manufacture it, in 2003. However, Ovation Pharmaceuticals have ceased their operations now, so the Winstrol products available today in the American markets are only generic and not pharmaceutical grade. Outside the USA, however, several large brands still manufacture and sell Winstrol. 

Genuine Stanozolol can be distinguished in water suspensions because it separates from the liquid into micrometer particles. These particles will fall to the bottom if the container is not disturbed for a few hours. The crystals have a milky white color. 

Winstrol can not only be used for humans, but it has veterinary uses as well. Weakened or injured animals can be treated with Winstrol in order to promote red blood cell count, strengthen bones, stimulate appetite, and enhance muscle growth. It has also reportedly been used to dope horses in US horse races. 

If your vet is willing to try this, he/she will need to order it from a compounding pharmacy. 



The dose should be 1 mg 2 times a day for a cat. If your cat is in poor shape and needs an immediate boost, start him on 2 mg x 2 times a day for a week or so, and then drop down to the lower dose. 



Your vet will undoubtedly say that Winstrol is known to cause liver damage. 



The first answer to this is, so what? FeLV will almost invariably result in the premature death of cats. The vets have nothing which is directly effective to fight FeLV. Things like Interferon may or may not assist but such a treatment is again a side treatment where you are hoping to boost your cat’s immune system, rather than a direct attack on the virus. It is also quite indirect in that IF the interferon helps, it will be more long term, and only if it manages to boost the immune system enough to permit your cat’s system to try and fight the virus, and when/if the virus is inhibited enough, then MAYBE (if the virus hasn’t already destroyed all the progenitor cells in the bone marrow) will red cell production begin to climb again. Winstrol is the only medication that I know of, (and believe me, I have looked!) that seems to work by turning back on those progenitor cells or possibly promoting the growth of new ones since it also works to enhance the production of bone cells (effective against osteoporosis). 



The second answer, regarding the liver damage, is that the only information about this is quite suspect, coming out of a very poorly designed research study where the cats in the study were given doses found effective on HUSKY SLED DOGS for lord’s sake! The cats were given a LOADING DOSE via intravenous injection, of 25 mg – more than 10 times the recommended daily dose for cats. That’s the only study which has found this supposed link between Winstrol and liver damage. And even in that study, with those remarkably ridiculous doses, the cats in that study only had elevated liver enzymes (no tumours, etc.) and the liver enzymes dropped back to normal levels when the Winstrol was discontinued. This is consistent with my experience as well. I refused to stop the Winstrol for my cat, when the enzymes went up, because he was going to die with the low red cell count he had. I kept him on Winstrol for around 10 months, before the red cells were in a normal range. During that ten month period, I would wean him down a few times, but ALWAYS the red cells would immediately drop again, so it was more than clear that it was the Winstrol making the numbers rise. So, in the end, he had Winstrol pretty much for the duration of 10 months and his liver enzymes went right back to normal again, once I discontinued the Winstrol – NO lasting damage. This was also my experience with a second cat with a nasal sarcoma, and where I used the Winstrol to keep her appetite up and reduce the swelling (she was 16). The enzymes went quite high at the outset of my use of Winstrol, but went back to normal when I weaned her off for a bit and then again when I ultimately took her off the Winstrol. 



Get the Winstrol if you can, and use it in combination with the prednisone (which I am told also helps to protect the liver when the Winstrol is used) and Doxycycline. 



Amani 



From: Felvtalk [ mailto:felvtalk-bounces at felineleukemia.org ] On Behalf Of Liz McCarty 
Sent: September-15-16 1:40 PM 
To: felvtalk at felineleukemia.org 
Subject: [Felvtalk] My baby recently diagnosed with FeLV 

Hi everyone, 

Looking for support, suggestions, and information. I've never had a cat with FeLV. We took our 1 year old, Hodor, to the vet because he seemed lethargic and in his stool there was a piece of floss that was red. At the vet things escalated and they told us he was severely anemic and would need a transfusion that day. I took off work and rushed him to a specialist. The vet there told us she would run an FeLV test before doing anything in case we wanted to avoid the extra tests and procedures. She told us he was FeLV positive and persistently talked to me and my fiance about euthanizing him which was out of the question for us. I took him to the vet thinking it was going to be minor and then she's talking to me about killing him! We went forward with the blood transfusion. It's been almost 3 weeks now. They had him on doxycycline in case there was a bacterial cause, and prednisone. Last week he started interferon... Does anyone have experience with that and know if it was effective? I also started him on Pet Tinic. Any other suggestions? Any insight into whether you think he will be able to pull through? He doesn't have cancer, they ran the tests but don't know if it's in the bone marrow. I'm scared. We have another one year old, unrelated, and they are best friends. It breaks my heart to think they might be separated. She's not FeLV positive. 

Additionally I have set up a go fund me to help with the costs we incurred, and I want to donate half to FeLV research if anyone is interested. 
http://www.gofundme.com/2mzdpgk 

Mainly looking for support and advice. Thank you in advance. 

Elizabeth McCarty, ASW #36438 

----- Original Message -----

From: dlgegg at windstream.net 
To: "Molly Mou" <mollymoumoo at yahoo.com>, felvtalk at felineleukemia.org 
Sent: Saturday, February 25, 2017 9:15:50 AM 
Subject: Re: [Felvtalk] FeLv Positive cat 

I haave had no problems with this, all I can offer is prayer. 

---- Molly Mou <mollymoumoo at yahoo.com> wrote: 
> I am new to the list. Three weeks ago my 5-year old Miakitty was diagnosed with FeLv. The ELISA test showed slightly + for FeLv. Itook her to the vet’s initially because her lymph nodes were raging – all ofthem premandibular, prescapular, inguinal all the way to the popliteals wereenlarged. A needle aspirate of the lymph nodes result was hyperplasia,no lymphosarcoma. White blood cell count was normal, but she was anemic, butnot to the point of needing a transfusion.I was devastated and stunned at this diagnosis because she(the whole litter) was tested as kittens for FIV and FeLv and were negative. Myvet said the disease can stay in the bone marrow. I have her brother who isasymptomatic – confusing. I haven’t had him tested yet for FeLv yet.My vet recommended treatment with Immunoregulin. Theprotocol per Plumb’s is an IV injection twice weekly for two weeks, then 1injection once weekly for 21 weeks. She is now in her 4th week oftreatment. For the first two weeks, her lymph nodes decreased and becamesofter. But after the 2nd week her lymph nodes are raging againdespite the treatments. She is eating well, but not very active. Has anyone had experience with this treatment or any othertreatment(s) or advice to help my little girl? Thanks in advance, Pat Peterson 


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