[Felvtalk] Epogen and similiars

[Nancy]

Robert, May I ask what his HCT is?  

~ Nancy ~

> On Sep 20, 2016, at 11:49 AM, Amani Oakley <aoakley at oakleylegal.com> wrote:
> 
> Yes, Robert, I would think that it makes sense to try to get ahead of the problem. Just purely on a logical basis, while the bone marrow is still able to produce red cells, get him started on the Epogen and see if that helps. I also would again recommend Doxycycline in the hopes that it would act to keep the viral load down.
> 
> Amani
> 
> -----Original Message-----
> From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of ROBERT CHAPEL
> Sent: September-20-16 6:53 AM
> To: felvtalk at felineleukemia.org
> Cc: felvtalk at felineleukemia.org
> Subject: Re: [Felvtalk] Epogen and similiars
> 
> 
> Amani...
> 
> I understand your reasoning and have no rebuttal as I had not really considered this...  As it makes sense to address anemia BEFORE it becomes life threatening perhaps it would make sense to start Epogen( or
> similar) well before all the progenitors are wiped out.... My young boy Yogi ( who is riddled with FeLV related problems... ) is mildly anemic and I was , in fact, considering starting the drug before his numbers drop too substantially......   Very aggravating that my current Vet appeared willing, initially, to write me  a script for Winstrol but took back the offer after she spoke to the clinics director...   Can't afford to keep changing Vets want someone with at least a " little " investment in my guy and who has a sense of his history...
> 
> On Mon, Sep 19, 2016 at 01:00 PM, felvtalk-request at felineleukemia.org
> wrote:
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>> Today's Topics:
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>>   1. FW:  Epogen and other RBC enhancing drugs.... (Amani Oakley)
>> 
>> 
>> ----------------------------------------------------------------------
>> 
>> Message: 1
>> Date: Mon, 19 Sep 2016 16:19:56 +0000
>> From: Amani Oakley To: "felvtalk at felineleukemia.org" Subject: 
>> [Felvtalk] FW:  Epogen and other RBC enhancing drugs....
>> Message-ID:
>>    
>> Content-Type: text/plain; charset="utf-8"
>> 
>> 
>> It's not the same, Robert, and I am not sure it would work. The Epogen 
>> acts on the kidneys to secrete erythropoietin, which is a hormone that 
>> tells the bone marrow to produce more red cells.
>> 
>> The problem, in my opinion, is that the FeLV infiltrates the red cell 
>> progenitor cells in the bone marrow and either kills them or takes 
>> them over so that they make viruses, not red cells. My hypothesis is 
>> that when the red cell production stops, it is because all the 
>> progenitor cells have been destroyed or taken over the by virus. Thus, 
>> giving Epogen probably won't be helpful, because the cells which 
>> normally respond to erythropoietin by creating more red cells, can no 
>> longer do so because the progenitor cells are damaged or dead and can 
>> no longer produce red cells.
>> 
>> Winstrol is known to be good for osteoporosis. My hypothesis is that 
>> it strengthens the bone marrow by encouraging the growth of new cells 
>> in the bone marrow. That would explain how red cell production gets 
>> started back up again with the use of Winstrol.
>> 
>> With the Epogen, it is causing more erythropoietin to be produced to 
>> "tell" the progenitor cells to produce red cells, but the progenitor 
>> cells are either dead or damaged by the virus and can no longer 
>> respond appropriately to the detection of higher levels of 
>> erythropoietin. Epogen might work if you start it before the bone 
>> marrow is really devastated - ie - before you get the big drop in red 
>> cells and haematocrit.
>> 
>> Fair warning though: this is all my hypothesis, based on my own 
>> observations, research and experience.
>> 
>> Amani
>> -----Original Message-----
>> From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf 
>> Of ROBERT CHAPEL
>> Sent: September-18-16 5:22 AM
>> To: felvtalk at felineleukemia.org
>> Cc: felvtalk at felineleukemia.org
>> Subject: Re: [Felvtalk] Epogen and other RBC enhancing drugs....
>> 
>> Wondering if anyone in the group has any experience with Epogen or 
>> Procrit ( and other such RBC enhancing drugs typically used with 
>> Kidney Failure patients)....?? It's appears to be quite a bit cheaper 
>> when used for veterinary purposes than human....?? As the go to drug 
>> for anemia in Kidney patients it would stand to reason that it "
>> should" work for Feline anemia......??? There will not be the same 
>> resistance to using this as we encounter attempting to procure 
>> Winstrol......
>> 
>> 
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>> ------------------------------
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>> End of Felvtalk Digest, Vol 29, Issue 21
>> ****************************************
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