[Felvtalk] doxy

[Jane Gannon]

Hi Amani.

Thanks for the article.  Sounds promising.  

Jane
  ----- Original Message ----- 
  From: Amani Oakley 
  To: felvtalk at felineleukemia.org 
  Sent: Tuesday, May 17, 2016 3:07 PM
  Subject: Re: [Felvtalk] doxy


  Hi Jane

   

  As I mentioned in my previous posts, I am aware that no antibiotic KILLS viruses. However, Doxycycline also interferes with RNA reproduction in ALL cells. In mammalian cells, we have two sites for RNA synthesis, and so when the Doxycycline blocks one of the sites, mammalian cells can still proceed with RNA synthesis. That isn't the case with bacterial, and other organisms like protozoa and mycoplasma. Doxycycline has been also found to block RNA synthesis in some viruses. For example, search online for the following article and you will see that scientific trials have shown that the Doxycycline (which is a tetracycline derivative) blocked the ability of the virus to enter cells and replicate. 

   

  Inhibitory effect of doxycycline against dengue virus replication in vitro - Arch Virol. May 29, 2013 - "Doxycycline is an antibiotic derived from tetracycline that possesses antimicrobial and anti-inflammatory activities. Antiviral activity of doxycycline against dengue virus has been previously reported."

   

  ". . . It is efficiently used to treat some tick-borne infections and is also recommended as a first line therapy for sexually transmitted diseases as herpes simplex infections [caused by a virus]. Combining doxycycline with monocaprin provides an effective treatment for herpes labialis [another virus], significantly reducing time to healing and pain compared to moncaprin alone. Furthermore, antiviral activity of doxycycline has been reported against retroviruses, and a significant reduction in retrovirus titer was observed after incubation of infected cells with doxycycline. Previous studies have shown that doxycycline inhibits dengue virus plaque formation disrupting the conformational changes in the viral envelope that are necessary for viral entry . . . In this study, we determined the anti-dengue properties of doxycycline against four dengue virus serotypes in vitro. The results showed that doxycycline interfered with dengue virus protease and impaired virus binding to the host cells, leading to reduced viral replication in infected cells. Taken together, our results form a strong basis to warrant further experimental and clinical investigations towards reducing dengue morbidity by utilizing doxycycline and anti-inflammatory activities."

   

  With some careful digging, you will find references to the use of doxycycline (and other tetracyclines) to inhibit viral replication. I don't have more time today to find more of these articles for you, but they are there for the finding.

   

  Amani

   

  From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of Jane Gannon
  Sent: May-17-16 4:44 PM
  To: felvtalk at felineleukemia.org
  Subject: [Felvtalk] doxy

   

  Doxycycline ia an antibiotic for bacterial infections, not for viral infections.  It works by interferring with the normal growth cycle of the bacteria preventing them from  reproducing and allowing the body to fight off the infection.  It is used against mycoplasma including mycoplasma haemofelis, whcih is a blood parasite that causes anemia and death in cats   I have had a couple of cats die from it and a couple that I have saved.   This disease is transmitted by fleas so it is important to use flea products on our cats.  Doxy should be given with food or on a full stomach to reduce chance of vomiting.  It is suggested that you give a syringe of water after pilling because it is possible for the tablets to become stuck in the esophagus which can cause irritaftion or scarring and can make it difficult for your cat to swallow.  I crush it and mix it with water and syringe it. 

   

  In the book "Secrets of a vet tech-the guide to low cost pet care when the cupboard is bare" by J C Farris, she tells that you can use fish meds on cats and purchase them on line or in some pet stores without a script  This includes doxy (fish doxy), amoxicillan (fish mox), metronidazole (fish zole), clindamycin (fish cin), cephalexen (fish flex), ciprofloxacin (fish flox) and others.  This is the same exact medication for dogs and cats.  She has alot of other great ideas in this book. Dosages for these medications for cats can be found on line. 

   

  I just had my 5 yr old positive, Tootsie, stop eating and drinking.  She had vomited for a couple of days before.  She had no fever and no symptoms of upper respiratory so I didn't want to start antibiotics. I tried everytlhing to get her to eat.  Then I remembered pepcid ac was prescribed by a vet years ago for another cat (not a positive) with the same symptoms, so I tried it on Tootsie.  Four days later she is looking for food and eating everything I give her.  This is also used for kidney cats that loose their appetite.  

   

  Now I am going to try pepcid ac on my older positive cat, Finn, who is recovering from a seizure and temporary blindness.  She is not eating well and I remember before she had her seizure she had vomited for a couple of days and was already not eating well.     I will let you know if it works.

   

  Jane

   


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