[Felvtalk] Bogie's First 5 days on Stanozolol

Sun Aug 28 00:15:17 CDT 2016

I had forgotten about the Doxycycline also.....which was part of Tigger's
treatment.

Ardy

From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of
Amani Oakley
Sent: Friday, August 26, 2016 5:13 PM
To: felvtalk at felineleukemia.org
Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol

Sherri

I also should have mentioned the very important requirement that the vet
should put Bogie on Doxycycline as well. I always forget this. I forget
because my Zander was originally on Doxycycline and it was not helping, and
I don't think it can on its own, so I always forget the vital role it played
in Zander's recovery. While the Winstrol/prednisone is building up the body
and increasing red cell production, Doxycycline acts to inhibit RNA
replication, which is how the virus reproduces. Doxycycline is an
antibiotic, and everyone will tell you that it can't kill a virus, and it
doesn't. However, it prevents the numbers of the virus from continuing to
climb, while the body is repairing itself.

This is a key part of the treatment in my opinion. Otherwise, as you're
fighting to increase the red cell count and the other cell lines with the
Winstrol, the virus just keeps killing other cells. (That's how viruses
replicate - they infiltrate a cell, and commandeer it's cellular machinery,
and "force" the cell to produce millions more viruses. The cell then
explodes, or dies, releasing all these new viruses into the system. The
Doxycycline helps to interfere with this process.)

Sorry - I should have mentioned this before (and I have in dozens of my
posts), but, of course, the stumbling block usually is getting the Winstrol.

Amani

From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of
Sherri Godschalk
Sent: August-26-16 5:34 PM
To: felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org> 
Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol

Amani,

Thanks for all the valuable information. It actually calms me.

He has a lab in house and these were the results from this week. (I don't
have any from the prior visits to the other vet, but the new vet does)

RBC          2.43 M/ul   6.65-12.2    LOW

HCT        15.3 %         30.3-52.3      LOW

HGB         5.3 g/dL       9.8-16.2      LOW

MCV       62.6 fl        35.9-53.1     HIGH

MCH      21.8 pg      11.8-17.3      HIGH

RETIC     61.5 K/ul     3.0-50.0      HIGH

LYM        7.75 K/uL    0.92-6.88    HIGH

MONO   1.58 K/uL    0.05-0.67    HIGH

EOS         0.10 K/uL   0.17-1.57     LOW

BASO      0.00 K/uL   0.01-.26       LOW

PLT             50 K/uL   151-600       LOW

I haven't got the chance to research what all of this means. There were
several other levels on this sheet that were all within range.  Do you see
ANYTHING positive in these results? The first 6 look very bad to me.

Thanks again for writing.

From: Felvtalk <felvtalk-bounces at felineleukemia.org
<mailto:felvtalk-bounces at felineleukemia.org> > on behalf of Amani Oakley
<aoakley at oakleylegal.com <mailto:aoakley at oakleylegal.com> >
Reply-To: <felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org>
>
Date: Friday, August 26, 2016 at 3:29 PM
To: "felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org> "
<felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org> >
Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol

Sherri

Don't be disappointed. The key is that the haematocrit is starting to rise
and is not going down any further. Remember how few days the drug has had to
work. It is literally having to go into bone marrow and turn back on
progenitor cells in the bone marrow that have been infiltrated by the FeLV
virus, and are therefore destroyed or inactive. Also, did he do a
reticulocyte count? That should hopefully also start going up because those
are one of the immature forms of the red cells. Another is nucleated red
blood cells. At maturity, the red cells lose the nucleus (except in birds
and maybe reptiles). However, the instrument used to count the red cells
cannot differentiate a nucleated red cell from a white cell (which will have
a nucleus) so unless there is a manual count done, the automated instrument
results may count any nucleated red cells as white cells. This isn't too
critical, but it will not show you whether any of these immature red cell
forms are developing.

Also, while the haematocrit is important, you should also look at the
platelet count (which, I remember correctly, was low for Bogie) and the
white cell counts. I found that the Winstrol started improving all the
different cell lines, though admittedly, it appeared that the improvement
started with the red cells.

I am not sure I agree with your vet taking Bogie off the Winstrol though,
because it is an anabolic steroid and is literally rebuilding bone, muscle,
etc. With a debilitated cat, I think you've got to keep them on for a long
while. However, your vet has been helpful and more progressive than most, so
. . . 

Amani

From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of
Sherri Godschalk
Sent: August-26-16 7:03 AM
To: felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org> 
Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol

Thanks Ardy.

We had Bogeys first blood test after 7 days and her HCT was only still at
15.4. Slight increase. She is pretty functional at this level. Still
sleeping a lot. But eats, goes up and down stairs, bats at the dogs. The vet
didn't seem surprised that it hadn't gone up more. It hadn't gone down.
Considers her "stable". He doesn't want to see her for a month to test
again. He wants her to be off of the Stanozolol for one week starting next
Wed and then put her back on it the following week for two more. 

I was a bit disappointed that her blood results weren't better although I
could tell just with her energy level that she hadn't improved much.
Hopefully she just needs more time on it for it to take hold. I wish there
was something more that I could do. I feel so helpless.

Thanks for writing,

From: Felvtalk <felvtalk-bounces at felineleukemia.org
<mailto:felvtalk-bounces at felineleukemia.org> > on behalf of Ardy Robertson
<ardyr at centurytel.net <mailto:ardyr at centurytel.net> >
Reply-To: <felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org>
>
Date: Friday, August 26, 2016 at 12:07 AM
To: <felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org> >
Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol

Best wishes to you Sherri and to Bogie!! I do believe this drug combo
(Stanozolol and Prednisone) helped my Tigger also, it's just that I started
him on it too late. Tigger's bloodwork showed amazing improvement but I
believe his diagnosis was very late since he had tested negative as a
kitten, and at age 5 years they told me he had it since kittenhood but must
have been shedding the virus when tested. I sincerely hope Bogie can benefit
from this treatment since she is younger at her diagnosis. Also very happy
that you have a cooperating vet!

Ardy

From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of
Amani Oakley
Sent: Sunday, August 21, 2016 9:30 PM
To: felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org> 
Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol

Hi Sherri

I am happy to hear of your experience so far, but like you, I held my breath
for a very long time with Zander.

Please keep us all updated.

Amani

From: Felvtalk [mailto:felvtalk-bounces at felineleukemia.org] On Behalf Of
Sherri Godschalk
Sent: August-21-16 10:36 PM
To: felvtalk at felineleukemia.org <mailto:felvtalk at felineleukemia.org> 
Subject: [Felvtalk] Bogie's First 5 days on Stanozolol

I wanted to update everyone here about how this medication is affecting the
health of my FELV positive 1 year old kitten.

Bogie got her diagnosis just under 3 weeks ago. The first vet I saw tried
Prednisone and an antibiotic for 2 weeks and it did nothing for here severe
anemia. (Her only symptom) I was told at that time that there was nothing
that could help her and to just keep her comfortable as she dies. 

Changed vets.

New vet.Was prescribed 2mg of Stanozolol once a day along with the Pred once
a day. This morning, Bogie got her 5th dose of Stanozolol. She appears to be
less anemic. Has more energy, sleeping less and more interested in playing
and is eating and drinking well enough on her own. Her gums are slightly
more pink as well. There hasn't been any side effects that I have seen with
this combination. Except I have to pill her twice a day but she is getting
used to that a little bit. 

I don't want to speak to soon, but I believe just from how she is acting,
that this drug is helping my kitten make some red blood cells. She goes in
this week for a blood test so I will know if it is actually doing that .
Today is the happiest day we have had in the house in over a month. 

I will reply to this thread to keep the group posted. 

Wish us luck!

Best.

Sherri

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