[Felvtalk] Interferon-Article that explains why I now give it 2x daily

[Gloria B. Lane]

Thanks very much for the article.  This is consistent with what I've  
heard, mostly in years past on this list, possibly from Tally (www.tallyville.com/interferon.html) 
.  It is Low Dose Oral Interferon alpha, as I understand drastically  
different from high dose injected interferon given to humans for  
cancer treatment.

The other protocols I've seen listed are 3 days on/3 off, and 7 days  
on/7 off.  I've seen folks express concern that cats will become  
"immune" to the interferon, if they're not off it for a while. One  
justification for daily use is that FELV cats don't have enough  
naturally occurring Interferon to support their immune systems.    Now  
that's just a theory I've seen posted on  this list, from years back.

Gloria





On Sep 30, 2009, at 2:10 AM, Alice Flowers wrote:

> Here are some excerpts from some research on Interferon-I have been  
> giving it 2x a day-orally 1 cc to Rosie and Murphy. I had been  
> giving it onece a day to the other 4 that passed away. I always give  
> it right before the canned food-they both come into the kitchen and  
> pester me, Murphy bangs the cabinet door until I get the little  
> syringe filled. Then they sit and wait for the little squirt, Rosie  
> will tilt her head sideways-she likes it squirted on the right side  
> of her mouth, I don't have to force them to take it, it's just the  
> routine. I even tasted it, just tastes like saline solutine-similar  
> to sinus rinse or saline nasal spray. I have not noticed any side  
> effects, except maybe lately, combined with the Imulan treatments  
> the last 2 weeks-they are playing much more and are awake for longer  
> periods and are looking for things to get into. They are making up  
> for being so sick the first year.
>
> WHY IS DAILY DOSING BETTER?
> Jere Hough
> Three Times Weekly Is A Terribly Poor Way to Dose Interferon....
> This is a great article and also discusses the development of longer  
> acting pegylated interferons to better manage the peak and valley  
> effects of the current generation of Interferons:
> “PEAKS AND VALLEYS - Because interferon has a half-life in serum of  
> only about 7 -10 hours. This means it peaks in the body at about 12  
> hours and is then rapidly metabolized and excreted. At 24 hours  
> after injection it is barely measurable. By 36 hours it is not  
> detectable with current measurements. During this peak the is a  
> rapid, dramatic drop in viral load. As the levels of interferons  
> quickly drop to negligible levels at about 24 hours viral loads  
> start rapidly climbing again. By 48 or especially 72 hours much of  
> the gain in viral reduction has been lost.
> In other words, viral loads in the body fluctuate directly and  
> rapidly along with levels of interferon in serum, and when plotted  
> on a graph look like a sine wave, or a roller coaster. This graph,  
> along with a description of this phenomena, can be viewed on many  
> websites and texts on the subject, including the http://www.roche-hepc.com/ 
>  page. These peaks and valleys have been followed for days in human  
> subjects, and are invariably similar in those who respond to IFN.
> As interferon levels go up viral loads go down immediately. Then as  
> IFN levels drop, viral loads increase again rapidly. In the period  
> from 24 to 48 hours viral loads peak to erase most of the gains  
> made. In standard TIW dosing the increase in viral loads is even  
> more pronounced during the 72 hour break once each week.”
> 1) NEVER give with food. Inteferon breaks down in the stomach with  
> stomach acid. Always squirt it directly into the mouth where it is  
> absorbed in the mouth and throat lining.
> #2) ALWAYS keep refridgerated. It's useless if it hits room  
> temperature. Keep unused dilutions frozen until needed. It's unknown  
> how long Interferon stays effective in the fridge. Keep unused  
> dilutions frozen until needed.
> #3) It's USELESS to do on/off dosing. It MUST be given every 24  
> hours to maintain consistent levels in the bloodstream. (See  
> excerpts below regarding peaks and valleys). It must be kept in the  
> blood at all times. On/Off protocols are worthless because it  
> progresses forward in times of no intervention.
>
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